失智症與認知功能

相關發表文獻使用 BiobServe Veiwer 系統研究主題。

Urinary and faecal metabolic characteristics in APP/PS1 transgenic mouse model of Alzheimer’s disease with and without cognitive decline

Y Zheng, Q Xu, Q Jin, Y Du, J Yan, H Gao, H Zheng – Biochemical and Biophysical …, 2022

Alzheimer’s disease (AD) has been considered to be a systematic metabolic disorder,
but little information is available about metabolic changes in the urine and feces. In
this study, we investigated urinary and faecal metabolic profiles in amyloid precursor …

Apolipoprotein E Isoform-Dependent Effects on Human Amyloid Precursor Protein/Aβ-Induced Behavioral Alterations and Cognitive Impairments and Insoluble …

S Holden, P Kundu, ERS Torres, R Sudhakar, D Krenik… – Frontiers in Aging …, 2022

Mice expressing human Amyloid Precursor Protein (APP) containing the dominant
Swedish and Iberian mutations (AppNL-F) or also Arctic mutation (AppNL-GF) show
neuropathology and hippocampus-dependent cognitive impairments pertinent to …

Metabolic and behavioral characterization of the APP23 mouse model of Alzheimer’s disease with regard to early therapeutic lifestyle interventions

S Schreyer – 2022

The risk of developing Alzheimer’s disease (AD) is increased in patients with type 2
diabetes mellitus. Both diseases share several common features, such as glucose
intolerance and insulin resistance. As cerebral glucose hypometabolism already …

Causal Evidence for a Role of Cerebellar Lobulus Simplex in Prefrontal-Hippocampal Interaction in Spatial Working Memory Decision-Making

Y Liu, SS McAfee, ME Van Der Heijden, M Dhamala… – The Cerebellum, 2022

Spatial working memory (SWM) is a cerebrocerebellar cognitive skill supporting
survival-relevant behaviors, such as optimizing foraging behavior by remembering
recent routes and visited sites. It is known that SWM decision-making in rodents …

Characterization of the new htau-KI mouse model for Alzheimer’s disease with a focus on the role of immune cells during progressing cerebral amyloidosis

S Barendrecht

… (Biobserve) and the animal was tracked using the Biobserve Viewer system. The
open field was a square area of 53.8 x 53.8 cm, with … infrared camera (Biobserve),
and the animal was tracked using the Biobserve Viewer system. A learning curve …

Somatodendritic release of cholecystokinin potentiates GABAergic synapses onto ventral tegmental area dopamine cells

VM Damonte, MB Pomrenze, C Casper, AM Wolfden… – bioRxiv, 2022

Neuropeptides are contained in nearly every neuron in the central nervous system
and can be released from somatodendritic sites as well as from nerve terminals.
Cholecystokinin (CCK), among the most abundant neuropeptides in the brain, is …

Investigating Cerebrocerebellar Neuronal Interactions in Freely Moving Mice Using Multi-electrode, Multi-site Recordings

Y Liu, BL Correia, MB Fox, DH Heck – Measuring Cerebellar Function, 2022

… For freely moving recordings, behavioral tasks were completed in an elevated plus
maze and recorded using the Viewer video system (Biobserve GmbH; Bonn, Germany).
Data was saved to a hard disk (W2100-HS16, Multichannel Systems; Germany). …

Cognitive impairment persists at least 1 year after juvenile rats are treated with methotrexate

J Wen, C Patel, F Diglio, K Baker, G Marshall, S Li… – Neuropharmacology, 2022

Methotrexate (MTX) is widely employed for children with cancer, but is also
associated with persistent cognitive deficits among survivors. The present study
investigated the mechanisms behind long-term cognitive dysfunction after juvenile …